[HTML][HTML] Contrasting immune responses mediate Campylobacter jejuni-induced colitis and autoimmunity
Campylobacter jejuni is a leading cause of foodborne enteritis that has been linked to the
autoimmune neuropathy, Guillain Barré syndrome (GBS). C57BL/6 interleukin (IL)-10+/+
and congenic IL-10−/− mice serve as C. jejuni colonization and colitis models, respectively,
but a mouse model for GBS is lacking. We demonstrate that IL-10−/− mice infected with a C.
jejuni colitogenic human isolate had significantly upregulated type 1 and 17 but not type 2
cytokines in the colon coincident with infiltration of phagocytes, T cells and innate lymphoid …
autoimmune neuropathy, Guillain Barré syndrome (GBS). C57BL/6 interleukin (IL)-10+/+
and congenic IL-10−/− mice serve as C. jejuni colonization and colitis models, respectively,
but a mouse model for GBS is lacking. We demonstrate that IL-10−/− mice infected with a C.
jejuni colitogenic human isolate had significantly upregulated type 1 and 17 but not type 2
cytokines in the colon coincident with infiltration of phagocytes, T cells and innate lymphoid …