Vitamin D promotes human extravillous trophoblast invasion in vitro
SY Chan, R Susarla, D Canovas, E Vasilopoulou… - Placenta, 2015 - Elsevier
Introduction Incomplete human extravillous trophoblast (EVT) invasion of the decidua and
maternal spiral arteries is characteristic of pre-eclampsia, a condition linked to low maternal
vitamin D status. It is hypothesized that dysregulated vitamin D action in uteroplacental
tissues disrupts EVT invasion leading to malplacentation. Methods This study assessed the
effects of the active vitamin D metabolite, 1, 25-dihydroxyvitamin D 3 (1, 25-D 3), and its
precursor, 25-hydroxyvitamin D 3 (25-D 3), on primary human EVT isolated from first …
maternal spiral arteries is characteristic of pre-eclampsia, a condition linked to low maternal
vitamin D status. It is hypothesized that dysregulated vitamin D action in uteroplacental
tissues disrupts EVT invasion leading to malplacentation. Methods This study assessed the
effects of the active vitamin D metabolite, 1, 25-dihydroxyvitamin D 3 (1, 25-D 3), and its
precursor, 25-hydroxyvitamin D 3 (25-D 3), on primary human EVT isolated from first …