[HTML][HTML] Kinetic investigations of the role of factor inhibiting hypoxia-inducible factor (FIH) as an oxygen sensor
H Tarhonskaya, AP Hardy, EA Howe, ND Loik… - Journal of Biological …, 2015 - ASBMB
The hypoxia-inducible factor (HIF) hydroxylases regulate hypoxia sensing in animals. In
humans, they comprise three prolyl hydroxylases (PHD1–3 or EGLN1–3) and factor
inhibiting HIF (FIH). FIH is an asparaginyl hydroxylase catalyzing post-translational
modification of HIF-α, resulting in reduction of HIF-mediated transcription. Like the PHDs,
FIH is proposed to have a hypoxia-sensing role in cells, enabling responses to changes in
cellular O 2 availability. PHD2, the most important human PHD isoform, is proposed to be …
humans, they comprise three prolyl hydroxylases (PHD1–3 or EGLN1–3) and factor
inhibiting HIF (FIH). FIH is an asparaginyl hydroxylase catalyzing post-translational
modification of HIF-α, resulting in reduction of HIF-mediated transcription. Like the PHDs,
FIH is proposed to have a hypoxia-sensing role in cells, enabling responses to changes in
cellular O 2 availability. PHD2, the most important human PHD isoform, is proposed to be …