[HTML][HTML] Altered plasma profile of antioxidant proteins as an early correlate of pancreatic β cell dysfunction
Insulin resistance and β cell dysfunction contribute to the pathogenesis of type 2 diabetes.
Unlike insulin resistance, β cell dysfunction remains difficult to predict and monitor, because
of the inaccessibility of the endocrine pancreas, the integrated relationship with insulin
sensitivity, and the paracrine effects of incretins. The goal of our study was to survey the
plasma response to a metabolic challenge in order to identify factors predictive of β cell
dysfunction. To this end, we combined (i) the power of unbiased iTRAQ (isobaric tag for …
Unlike insulin resistance, β cell dysfunction remains difficult to predict and monitor, because
of the inaccessibility of the endocrine pancreas, the integrated relationship with insulin
sensitivity, and the paracrine effects of incretins. The goal of our study was to survey the
plasma response to a metabolic challenge in order to identify factors predictive of β cell
dysfunction. To this end, we combined (i) the power of unbiased iTRAQ (isobaric tag for …