[HTML][HTML] Cytosolic accumulation of small nucleolar RNAs (snoRNAs) is dynamically regulated by NADPH oxidase
CL Holley, MW Li, BS Scruggs, SJ Matkovich… - Journal of Biological …, 2015 - ASBMB
Small nucleolar RNAs (snoRNAs) guide nucleotide modifications of cellular RNAs in the
nucleus. We previously showed that box C/D snoRNAs from the Rpl13a locus are
unexpected mediators of physiologic oxidative stress, independent of their predicted
ribosomal RNA modifications. Here we demonstrate that oxidative stress induced by
doxorubicin causes rapid cytoplasmic accumulation of the Rpl13a snoRNAs through a
mechanism that requires superoxide and a nuclear splice variant of NADPH oxidase. RNA …
nucleus. We previously showed that box C/D snoRNAs from the Rpl13a locus are
unexpected mediators of physiologic oxidative stress, independent of their predicted
ribosomal RNA modifications. Here we demonstrate that oxidative stress induced by
doxorubicin causes rapid cytoplasmic accumulation of the Rpl13a snoRNAs through a
mechanism that requires superoxide and a nuclear splice variant of NADPH oxidase. RNA …