A hitherto unrecognized entity manifested by complete absence of gamma globulin with
otherwise normal serum proteins and recurrent pneumococcal sepsis is described in an 8
year old male. The patient appears to be normal in other respects and after extensive study
no structural or functional change could be demonstrated in any body system although
gamma globulin by electrophoretic analysis of his serum was consistently absent. He was
unable to produce antibody for the pneumococcus with the four antigenic substances used; …