Background aims Cancer is one of the greatest health challenges facing the world today
with> 10 million new cases of cancer every year. The self-renewal, tumor-homing ability and
low immunogenicity of mesenchymal stromal cells (MSCs) make them potential delivery
candidates for suicide genes for anti-tumor therapy. However, unstable supply and short life
span of adult MSCs in vitro have limited this therapeutic potential. In this study, we aimed to
evaluate if immortalization of human fetal bone marrow-derived mesenchymal stromal cells …