[HTML][HTML] New insights into signalling-pathway alterations in rhabdomyosarcoma
B Zhu, JK Davie - British Journal of Cancer, 2015 - nature.com
B Zhu, JK Davie
British Journal of Cancer, 2015•nature.comRhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children and young
adults. Several recent studies have shed new light on the alterations in signalling pathways
and the downstream effects of these pathway alterations in RMS. Many of these effects
converge on the fibroblast growth factor and insulin-like growth-factor pathways. These new
findings improve the current understanding of RMS, thus offering novel potential therapeutic
targets and strategies that may improve the outcome for patients with RMS.
adults. Several recent studies have shed new light on the alterations in signalling pathways
and the downstream effects of these pathway alterations in RMS. Many of these effects
converge on the fibroblast growth factor and insulin-like growth-factor pathways. These new
findings improve the current understanding of RMS, thus offering novel potential therapeutic
targets and strategies that may improve the outcome for patients with RMS.
Abstract
Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children and young adults. Several recent studies have shed new light on the alterations in signalling pathways and the downstream effects of these pathway alterations in RMS. Many of these effects converge on the fibroblast growth factor and insulin-like growth-factor pathways. These new findings improve the current understanding of RMS, thus offering novel potential therapeutic targets and strategies that may improve the outcome for patients with RMS.
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