A key pathogenic role for the STAT1/T-bet signaling pathway in T-cell–mediated liver inflammation
J Siebler, S Wirtz, S Klein, M Protschka, M Blessing… - Hepatology, 2003 - Elsevier
TH1 cytokines have been suggested to contribute to the pathogenesis of T-cell-mediated
liver injury and inflammation. However, the molecular signaling pathways involved in such
injury are still poorly understood. In the present study, we investigated the role of the
STAT1/T-bet signaling pathway in a murine model of T-cell-mediated liver inflammation
induced by the application of concanavalin A (Con A) using newly created STAT1 transgenic
mice as well as STAT1-and T-bet-deficient mice. Liver injury induced by Con A was …
liver injury and inflammation. However, the molecular signaling pathways involved in such
injury are still poorly understood. In the present study, we investigated the role of the
STAT1/T-bet signaling pathway in a murine model of T-cell-mediated liver inflammation
induced by the application of concanavalin A (Con A) using newly created STAT1 transgenic
mice as well as STAT1-and T-bet-deficient mice. Liver injury induced by Con A was …