Expression of the invasion factor laminin γ2 in colorectal carcinomas is regulated by β-catenin

F Hlubek, A Jung, N Kotzor, T Kirchner, T Brabletz - Cancer Research, 2001 - AACR
F Hlubek, A Jung, N Kotzor, T Kirchner, T Brabletz
Cancer Research, 2001AACR
The migration-inducing γ2 chain of laminin-5, one of the best known invasion markers, is
strongly overexpressed in disseminating and infiltrating tumor cells at the invasive front of
colorectal carcinomas. The same tumor cells show nuclear accumulation of the oncoprotein
β-catenin, which together with T-cell factor-DNA-binding proteins, functions as
transcriptional activator of genes involved in tumor progression. Here we show that β-
catenin activates the human laminin-5 γ2 gene through two T-cell factor-binding elements in …
Abstract
The migration-inducing γ2 chain of laminin-5, one of the best known invasion markers, is strongly overexpressed in disseminating and infiltrating tumor cells at the invasive front of colorectal carcinomas. The same tumor cells show nuclear accumulation of the oncoprotein β-catenin, which together with T-cell factor-DNA-binding proteins, functions as transcriptional activator of genes involved in tumor progression. Here we show that β-catenin activates the human laminin-5 γ2 gene through two T-cell factor-binding elements in a synergistic manner together with hepatocyte growth factor and conclude that laminin-5 γ2 is another important target gene of nuclear β-catenin during tumor progression.
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