[HTML][HTML] Fibronectin protects prostate cancer cells from tumor necrosis factor-α-induced apoptosis via the AKT/survivin pathway
M Fornaro, J Plescia, S Chheang, G Tallini… - Journal of Biological …, 2003 - ASBMB
Integrins are cell surface heterodimeric transmembrane receptors that, in addition to
mediating cell adhesion to extracellular matrix proteins modulate cell survival. This
mechanism may be exploited in cancer where evasion from apoptosis invariably contributes
to cellular transformation. The molecular mechanisms responsible for matrix-induced
survival signals begin to be elucidated. Here we report that the inhibitor of apoptosis survivin
is expressed in vitro in human prostate cell lines with the highest levels present in …
mediating cell adhesion to extracellular matrix proteins modulate cell survival. This
mechanism may be exploited in cancer where evasion from apoptosis invariably contributes
to cellular transformation. The molecular mechanisms responsible for matrix-induced
survival signals begin to be elucidated. Here we report that the inhibitor of apoptosis survivin
is expressed in vitro in human prostate cell lines with the highest levels present in …