The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
MM Mihaylova, RJ Shaw - Nature cell biology, 2011 - nature.com
Nature cell biology, 2011•nature.com
One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-
activated protein kinase (AMPK), which is activated when intracellular ATP production
decreases. AMPK has critical roles in regulating growth and reprogramming metabolism,
and has recently been connected to cellular processes such as autophagy and cell polarity.
Here we review a number of recent breakthroughs in the mechanistic understanding of
AMPK function, focusing on a number of newly identified downstream effectors of AMPK.
activated protein kinase (AMPK), which is activated when intracellular ATP production
decreases. AMPK has critical roles in regulating growth and reprogramming metabolism,
and has recently been connected to cellular processes such as autophagy and cell polarity.
Here we review a number of recent breakthroughs in the mechanistic understanding of
AMPK function, focusing on a number of newly identified downstream effectors of AMPK.
Abstract
One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-activated protein kinase (AMPK), which is activated when intracellular ATP production decreases. AMPK has critical roles in regulating growth and reprogramming metabolism, and has recently been connected to cellular processes such as autophagy and cell polarity. Here we review a number of recent breakthroughs in the mechanistic understanding of AMPK function, focusing on a number of newly identified downstream effectors of AMPK.
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