Behind the wheel and under the hood: functions of cyclin-dependent kinases in response to DNA damage

L Wohlbold, RP Fisher - DNA repair, 2009 - Elsevier
Cell division and the response to genotoxic stress are intimately connected in eukaryotes,
for example, by checkpoint pathways that signal the presence of DNA damage or its ongoing
repair to the cell cycle machinery, leading to reversible arrest or apoptosis. Recent studies
reveal another connection: the cyclin-dependent kinases (CDKs) that govern both DNA
synthesis (S) phase and mitosis directly coordinate DNA repair processes with progression
through the cell cycle. In both mammalian cells and yeast, the two major modes of double …