Background Rapid desensitization transiently prevents severe allergic reactions, allowing
administration of life-saving therapies in previously sensitized patients. However, the
mechanisms underlying successful rapid desensitization are not fully understood. Objectives
We sought to investigate whether the mast cell (MC) is an important target of rapid
desensitization in mice sensitized to exhibit IgE-dependent passive systemic anaphylaxis in
vivo and to investigate the antigen specificity and underlying mechanisms of rapid …