Dynamin–related protein 1 deficiency improves mitochondrial fitness and protects against progression of diabetic nephropathy
BA Ayanga, SS Badal, Y Wang, DL Galvan… - Journal of the …, 2016 - journals.lww.com
Mitochondrial fission has been linked to the pathogenesis of diabetic nephropathy (DN).
However, how mitochondrial fission affects progression of DN in vivo is unknown. Here, we
report the effect of conditional podocyte–specific deletion of dynamin-related protein 1
(Drp1), an essential component of mitochondrial fission, on the pathogenesis and
progression of DN. Inducible podocyte–specific deletion of Drp1 in diabetic mice decreased
albuminuria and improved mesangial matrix expansion and podocyte morphology …
However, how mitochondrial fission affects progression of DN in vivo is unknown. Here, we
report the effect of conditional podocyte–specific deletion of dynamin-related protein 1
(Drp1), an essential component of mitochondrial fission, on the pathogenesis and
progression of DN. Inducible podocyte–specific deletion of Drp1 in diabetic mice decreased
albuminuria and improved mesangial matrix expansion and podocyte morphology …