Mitochondrial biogenesis in kidney disease

JM Weinberg - Journal of the American Society of Nephrology, 2011 - journals.lww.com
The transcriptional regulation of mitochondrial biogenesis by normal metabolic adaptation or
injury has been clarified over the past decade. Mitochondrial biogenesis and its attendant
processes enhance metabolic pathways such as fatty acid oxidation and increase
antioxidant defense mechanisms that ameliorate injury from aging, tissue hypoxia, and
glucose or fatty acid overload, all of which contribute to the pathogenesis of acute and
chronic kidney disease. There has been considerable interest in peroxisome proliferator …