Effect of a high-fructose weight-maintaining diet on lipogenesis and liver fat
JM Schwarz, SM Noworolski, MJ Wen… - The Journal of …, 2015 - academic.oup.com
JM Schwarz, SM Noworolski, MJ Wen, A Dyachenko, JL Prior, ME Weinberg, LA Herraiz…
The Journal of Clinical Endocrinology & Metabolism, 2015•academic.oup.comContext: Consumption of high-fructose diets promotes hepatic fatty acid synthesis (de novo
lipogenesis [DNL]) and an atherogenic lipid profile. It is unclear whether these effects occur
independent of positive energy balance and weight gain. Objectives: We compared the
effects of a high-fructose,(25% of energy content) weight-maintaining diet to those of an
isocaloric diet with the same macronutrient distribution but in which complex carbohydrate
(CCHO) was substituted for fructose. Design, Setting, and Participants: Eight healthy men …
lipogenesis [DNL]) and an atherogenic lipid profile. It is unclear whether these effects occur
independent of positive energy balance and weight gain. Objectives: We compared the
effects of a high-fructose,(25% of energy content) weight-maintaining diet to those of an
isocaloric diet with the same macronutrient distribution but in which complex carbohydrate
(CCHO) was substituted for fructose. Design, Setting, and Participants: Eight healthy men …
Context
Consumption of high-fructose diets promotes hepatic fatty acid synthesis (de novo lipogenesis [DNL]) and an atherogenic lipid profile. It is unclear whether these effects occur independent of positive energy balance and weight gain.
Objectives
We compared the effects of a high-fructose, (25% of energy content) weight-maintaining diet to those of an isocaloric diet with the same macronutrient distribution but in which complex carbohydrate (CCHO) was substituted for fructose.
Design, Setting, and Participants
Eight healthy men were studied as inpatients for consecutive 9-day periods. Stable isotope tracers were used to measure fractional hepatic DNL and endogenous glucose production (EGP) and its suppression during a euglycemic-hyperinsulinemic clamp. Liver fat was measured by magnetic resonance spectroscopy.
Results
Weight remained stable. Regardless of the order in which the diets were fed, the high-fructose diet was associated with both higher DNL (average, 18.6 ± 1.4% vs 11.0 ± 1.4% for CCHO; P = .001) and higher liver fat (median, +137% of CCHO; P = .016) in all participants. Fasting EGP and insulin-mediated glucose disposal did not differ significantly, but EGP during hyperinsulinemia was greater (0.60 ± 0.07 vs 0.46 ± 0.06 mg/kg/min; P = .013) with the high-fructose diet, suggesting blunted suppression of EGP.
Conclusion
Short-term high-fructose intake was associated with increased DNL and liver fat in healthy men fed weight-maintaining diets.
Oxford University Press