Hepatic glucose and lipid metabolism are altered in metabolic disease (eg obesity,
metabolic syndrome, and Type 2 diabetes). Insulin-dependent regulation of glucose
metabolism is impaired. In contrast, lipogenesis, hypertriglyceridemia, and hepatic steatosis
are increased. Because insulin promotes lipogenesis and liver fat accumulation, to explain
the elevation in plasma and tissue lipids, investigators have suggested the presence of
pathway-selective insulin resistance. In this model, insulin signaling to glucose metabolism …