MicroRNAs as a diagnostic tool for heart failure and atrial fibrillation
LT Weckbach, U Grabmaier, S Clauss… - Current Opinion in …, 2016 - Elsevier
Highlights•miR423-5p discriminated patients with HF from those with other causes of
dyspnea.•miRNA-related pathophysiological mechanisms of AF were shown for miR-21 and
miR-29b.•No consistent evidence for one particular miRNA as biomarker could be
provided.•No harmonized methodological standards for the assessment of miRNAs in the
blood exist.•Larger trials to establish miRNAs as clinically usable biomarkers are
required.MicroRNAs (miRNAs) are small non-coding RNAs, which are directly involved in …
dyspnea.•miRNA-related pathophysiological mechanisms of AF were shown for miR-21 and
miR-29b.•No consistent evidence for one particular miRNA as biomarker could be
provided.•No harmonized methodological standards for the assessment of miRNAs in the
blood exist.•Larger trials to establish miRNAs as clinically usable biomarkers are
required.MicroRNAs (miRNAs) are small non-coding RNAs, which are directly involved in …