A novel sequence found at the 3′-terminus of hepatitis C virus genome
T Tanaka, N Kato, MJ Cho, K Shimotohno - Biochemical and biophysical …, 1995 - Elsevier
T Tanaka, N Kato, MJ Cho, K Shimotohno
Biochemical and biophysical research communications, 1995•ElsevierThe 3′ end region of positive-strand RNA-virus genomes is implicated in the initiation of
genomic replication. We analyzed the extreme 3′ end of the hepatitis C virus (HCV)
genome by primer extension of the 5′ end region of the antigenomic strand RNA found in
infected liver. We discovered a novel sequence present downstream of the poly (U) stretch
that was previously considered to be the 3′ end structure of the HCV genome. The novel
sequence was 98 nucleotides long and had no significant homology with any known …
genomic replication. We analyzed the extreme 3′ end of the hepatitis C virus (HCV)
genome by primer extension of the 5′ end region of the antigenomic strand RNA found in
infected liver. We discovered a novel sequence present downstream of the poly (U) stretch
that was previously considered to be the 3′ end structure of the HCV genome. The novel
sequence was 98 nucleotides long and had no significant homology with any known …
The 3′ end region of positive-strand RNA-virus genomes is implicated in the initiation of genomic replication. We analyzed the extreme 3′ end of the hepatitis C virus (HCV) genome by primer extension of the 5′ end region of the antigenomic strand RNA found in infected liver. We discovered a novel sequence present downstream of the poly(U) stretch that was previously considered to be the 3′ end structure of the HCV genome. The novel sequence was 98 nucleotides long and had no significant homology with any known sequences, viral or nonviral. The discovery of this novel tail on the HCV genome should contribute to the study of HCV replication.
Elsevier