Mechanisms and treatment of allergic disease in the big picture of regulatory T cells
Various populations of regulatory T (Treg) cells have been shown to play a central role in the
maintenance of peripheral homeostasis and the establishment of controlled immune
responses. Their identification as key regulators of immunologic processes in peripheral
tolerance to allergens has opened an important era in the prevention and treatment of
allergic diseases. Both naturally occurring CD4+ CD25+ Treg cells and inducible
populations of allergen-specific, IL-10–secreting Treg type 1 (TR1) cells inhibit allergen …
maintenance of peripheral homeostasis and the establishment of controlled immune
responses. Their identification as key regulators of immunologic processes in peripheral
tolerance to allergens has opened an important era in the prevention and treatment of
allergic diseases. Both naturally occurring CD4+ CD25+ Treg cells and inducible
populations of allergen-specific, IL-10–secreting Treg type 1 (TR1) cells inhibit allergen …