Oral immunotherapy induces IgG antibodies that act through FcγRIIb to suppress IgE-mediated hypersensitivity
OT Burton, SL Logsdon, JS Zhou… - Journal of allergy and …, 2014 - Elsevier
Background Food-induced anaphylaxis is triggered by specific IgE antibodies.
Paradoxically, some subjects with significant IgE levels can ingest allergenic foods without
incident. Similarly, subjects completing oral immunotherapy (OIT) tolerate food challenges
despite persistent high-titer food-specific IgE. Objective We sought to test whether IgG
antibodies induced by food immunotherapy prevent food-induced anaphylaxis and whether
this occurs through the inhibitory receptor FcγRIIb. Methods Food allergy–susceptible …
Paradoxically, some subjects with significant IgE levels can ingest allergenic foods without
incident. Similarly, subjects completing oral immunotherapy (OIT) tolerate food challenges
despite persistent high-titer food-specific IgE. Objective We sought to test whether IgG
antibodies induced by food immunotherapy prevent food-induced anaphylaxis and whether
this occurs through the inhibitory receptor FcγRIIb. Methods Food allergy–susceptible …