Inflammatory bowel disease (IBD) is a common and debilitating clinical disorder comprising
ulcerative colitis and Crohn's disease. IBD occurs when inappropriate immunological activity
in the intestinal mucosa results in epithelial barrier dysfunction leading to exposure of the
mucosal immune system to luminal antigenic material. This in turn results in the cycles of
inflammation and further barrier dysfunction which underlie disease progression. Although
significant therapeutic advances have been made over the last decade, current …