[HTML][HTML] HIF-1 and tumour radiosensitivity
BJ Moeller, MW Dewhirst - British journal of cancer, 2006 - nature.com
BJ Moeller, MW Dewhirst
British journal of cancer, 2006•nature.comAbstract Hypoxia-inducible factor-1 (HIF-1) plays important roles in regulating
radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here,
we discuss the rationale for, and the potential pitfalls of, combining HIF-1 blockade with
radiotherapy. In doing so, we describe clinical scenarios in which HIF-1 inhibition might
optimise tumour radiosensitivity.
radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here,
we discuss the rationale for, and the potential pitfalls of, combining HIF-1 blockade with
radiotherapy. In doing so, we describe clinical scenarios in which HIF-1 inhibition might
optimise tumour radiosensitivity.
Abstract
Hypoxia-inducible factor-1 (HIF-1) plays important roles in regulating radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here, we discuss the rationale for, and the potential pitfalls of, combining HIF-1 blockade with radiotherapy. In doing so, we describe clinical scenarios in which HIF-1 inhibition might optimise tumour radiosensitivity.
nature.com