[HTML][HTML] Intratumor hypoxia promotes immune tolerance by inducing regulatory T cells via TGF-β1 in gastric cancer

B Deng, JM Zhu, Y Wang, TT Liu, YB Ding, WM Xiao… - PloS one, 2013 - journals.plos.org
B Deng, JM Zhu, Y Wang, TT Liu, YB Ding, WM Xiao, GT Lu, P Bo, XZ Shen
PloS one, 2013journals.plos.org
Regulatory T cell (Treg)-mediated immunosuppression represents one of the crucial tumor
immune evasion mechanisms and is a main obstacle for successful tumor immunotherapy.
Hypoxia, a common feature of solid tumors, has been associated with potentiated
immunosuppression, decreased therapeutic response, malignant progression and local
invasion. Unfortunately, the link between hypoxia and Treg-mediated immune tolerance in
gastric cancer remains poorly understood. In our study, Tregs and hypoxia inducible factor …
Regulatory T cell (Treg)-mediated immunosuppression represents one of the crucial tumor immune evasion mechanisms and is a main obstacle for successful tumor immunotherapy. Hypoxia, a common feature of solid tumors, has been associated with potentiated immunosuppression, decreased therapeutic response, malignant progression and local invasion. Unfortunately, the link between hypoxia and Treg-mediated immune tolerance in gastric cancer remains poorly understood. In our study, Tregs and hypoxia inducible factor-1α were found to be positively correlated with each other and were increased with the tumor progression. A subsequent in vitro study indicated that supernatants derived from gastric cancer cells under hypoxic condition, could induce the expression of Foxp3 via TGF-β1. These findings confirmed the crucial role of Tregs as a therapeutic target in gastric cancer therapy and provided helpful thoughts for the design of immunotherapy for gastric cancer in the future.
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