[HTML][HTML] Tight junction proteins form large complexes and associate with the cytoskeleton in an ATP depletion model for reversible junction assembly
T Tsukamoto, SK Nigam - Journal of Biological Chemistry, 1997 - ASBMB
A key feature of the ischemic epithelial cell phenotype is the disruption of tight junctions (TJ).
In a Manin-Darby canine kidney cell model for ischemia-reperfusion/hypoxia-reoxygenation
injury which employs inhibitors of glycolysis (2-deoxy-d-glucose) and oxidative
phosphorylation (antimycin A), transepithelial electrical resistance, a measure of TJ integrity,
dropped rapidly, correlating well with declining ATP levels. Although immunocytochemical
studies revealed only subtle changes in the distribution of the TJ proteins, zonula occludens …
In a Manin-Darby canine kidney cell model for ischemia-reperfusion/hypoxia-reoxygenation
injury which employs inhibitors of glycolysis (2-deoxy-d-glucose) and oxidative
phosphorylation (antimycin A), transepithelial electrical resistance, a measure of TJ integrity,
dropped rapidly, correlating well with declining ATP levels. Although immunocytochemical
studies revealed only subtle changes in the distribution of the TJ proteins, zonula occludens …