Regenerating skeletal muscle cells express insulin‐like growth factor I

E Jennische, HA Hansson - Acta Physiologica Scandinavica, 1987 - Wiley Online Library
E Jennische, HA Hansson
Acta Physiologica Scandinavica, 1987Wiley Online Library
The expression of the trophic peptide insulin‐like growth factor I (IGF‐I; somatomedin C) was
investigated in the regenerating soleus muscle of mice after injury by the snake venom
taipoxin. No specific IGF‐I immunoreactivity was observed in muscle cells during control
conditions. Within 2 days after taipoxin injection, IGF‐I immunoreactivity could be
demonstrated in activated satellite cells. Myoblasts and myotubes expressed high IGF‐I
immunoreactivity. The IGF‐I immunoreactivity was strictly cyto‐plasmatic and obviously …
The expression of the trophic peptide insulin‐like growth factor I (IGF‐I; somatomedin C) was investigated in the regenerating soleus muscle of mice after injury by the snake venom taipoxin. No specific IGF‐I immunoreactivity was observed in muscle cells during control conditions. Within 2 days after taipoxin injection, IGF‐I immunoreactivity could be demonstrated in activated satellite cells. Myoblasts and myotubes expressed high IGF‐I immunoreactivity. The IGF‐I immunoreactivity was strictly cyto‐plasmatic and obviously associated with polyribosomes. No vesicular or membraneous IGF‐I immunoreactivity could be demonstrated. It is concluded that IGF‐I is synthesized in myogenic cells during skeletal muscle regeneration. It is suggested that IGF‐I exerts its effects on skeletal muscle mainly by autocrine mechanisms.
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