[HTML][HTML] Chylomicron-sized lipid particles are formed in the setting of apolipoprotein B deficiency

RL Hamilton, JS Wong, CM Cham, LB Nielsen… - Journal of lipid …, 1998 - ASBMB
The mechanisms for packaging large quantities of neutral lipids into apolipoprotein (apo) B-
containing lipoproteins (chylomicrons or VLDL) are incompletely understood. However,
several lines of evidence have suggested that the addition of core lipids to apoB to form a
lipoprotein particle within the endoplasmic reticulum (ER) may involve two steps: first, the
addition of small amounts of core lipids to membrane-bound apoB, generating a lipid-poor,
small apoB-containing particle, and second, the fusion of that particle with a larger …