Fighting against the dark side of neutrophil extracellular traps in disease: manoeuvres for host protection
M Saffarzadeh, KT Preissner - Current opinion in hematology, 2013 - journals.lww.com
M Saffarzadeh, KT Preissner
Current opinion in hematology, 2013•journals.lww.comOn the basis of the type of the disease and its severity as well as the outcome of NET
generation, different therapeutic strategies may be considered to dampen the inauspicious
consequences of exaggerated NET formation and function. Applying combinations of
compounds that aim to decrease the adverse activity of DNA and NET-associated
proteins/enzymes may increase the efficiency of treatment.
generation, different therapeutic strategies may be considered to dampen the inauspicious
consequences of exaggerated NET formation and function. Applying combinations of
compounds that aim to decrease the adverse activity of DNA and NET-associated
proteins/enzymes may increase the efficiency of treatment.
Summary
On the basis of the type of the disease and its severity as well as the outcome of NET generation, different therapeutic strategies may be considered to dampen the inauspicious consequences of exaggerated NET formation and function. Applying combinations of compounds that aim to decrease the adverse activity of DNA and NET-associated proteins/enzymes may increase the efficiency of treatment.
Lippincott Williams & Wilkins