NETosis: how vital is it?
In this review, we examine the evidence that neutrophil extracellular traps (NETs) play a
critical role in innate immunity. We summarize how NETs are formed in response to various
stimuli and provide evidence that NETosis is not universally a cell death pathway. Here we
describe at least 2 different mechanisms by which NETs are formed, including a suicide lytic
NETosis and a live cell or vital NETosis. We also evaluate the evidence for NETs in catching
and killing pathogens. Finally, we examine how infections are related to the development of …
critical role in innate immunity. We summarize how NETs are formed in response to various
stimuli and provide evidence that NETosis is not universally a cell death pathway. Here we
describe at least 2 different mechanisms by which NETs are formed, including a suicide lytic
NETosis and a live cell or vital NETosis. We also evaluate the evidence for NETs in catching
and killing pathogens. Finally, we examine how infections are related to the development of …
Abstract
In this review, we examine the evidence that neutrophil extracellular traps (NETs) play a critical role in innate immunity. We summarize how NETs are formed in response to various stimuli and provide evidence that NETosis is not universally a cell death pathway. Here we describe at least 2 different mechanisms by which NETs are formed, including a suicide lytic NETosis and a live cell or vital NETosis. We also evaluate the evidence for NETs in catching and killing pathogens. Finally, we examine how infections are related to the development of autoimmune and vasculitic diseases through unintended but detrimental bystander damage resulting from NET release.
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