[HTML][HTML] Myotubularin regulates Akt-dependent survival signaling via phosphatidylinositol 3-phosphate
GL Razidlo, D Katafiasz, GS Taylor - Journal of Biological Chemistry, 2011 - ASBMB
Myotubularin is a 3-phosphoinositide phosphatase that is mutated in X-linked myotubular
myopathy, a severe neonatal disorder in which skeletal muscle development and/or
regeneration is impaired. In this report we provide evidence that siRNA-mediated silencing
of myotubularin expression markedly inhibits growth factor-stimulated Akt phosphorylation,
leading to activation of caspase-dependent pro-apoptotic signaling in HeLa cells and
primary human skeletal muscle myotubes. Myotubularin silencing also inhibits Akt …
myopathy, a severe neonatal disorder in which skeletal muscle development and/or
regeneration is impaired. In this report we provide evidence that siRNA-mediated silencing
of myotubularin expression markedly inhibits growth factor-stimulated Akt phosphorylation,
leading to activation of caspase-dependent pro-apoptotic signaling in HeLa cells and
primary human skeletal muscle myotubes. Myotubularin silencing also inhibits Akt …