[HTML][HTML] Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism
TD Baird, RC Wek - Advances in nutrition, 2012 - Elsevier
Regulation of mRNA translation is a rapid and effective means to couple changes in the
cellular environment with global rates of protein synthesis. In response to stresses, such as
nutrient deprivation and accumulation of misfolded proteins in the endoplasmic reticulum,
phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α~ P) reduces general
translation initiation while facilitating the preferential translation of select transcripts, such as
that encoding activating transcription factor 4 (ATF4), a transcriptional activator of genes …
cellular environment with global rates of protein synthesis. In response to stresses, such as
nutrient deprivation and accumulation of misfolded proteins in the endoplasmic reticulum,
phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α~ P) reduces general
translation initiation while facilitating the preferential translation of select transcripts, such as
that encoding activating transcription factor 4 (ATF4), a transcriptional activator of genes …