Uncovering the mysteries of hantavirus infections

A Vaheri, T Strandin, J Hepojoki, T Sironen… - Nature Reviews …, 2013 - nature.com
A Vaheri, T Strandin, J Hepojoki, T Sironen, H Henttonen, S Mäkelä, J Mustonen
Nature Reviews Microbiology, 2013nature.com
Hantaviruses are negative-sense single-stranded RNA viruses that infect many species of
rodents, shrews, moles and bats. Infection in these reservoir hosts is almost asymptomatic,
but some rodent-borne hantaviruses also infect humans, causing either haemorrhagic fever
with renal syndrome (HFRS) or hantavirus cardiopulmonary syndrome (HCPS). In this
Review, we discuss the basic molecular properties and cell biology of hantaviruses and offer
an overview of virus-induced pathology, in particular vascular leakage and …
Abstract
Hantaviruses are negative-sense single-stranded RNA viruses that infect many species of rodents, shrews, moles and bats. Infection in these reservoir hosts is almost asymptomatic, but some rodent-borne hantaviruses also infect humans, causing either haemorrhagic fever with renal syndrome (HFRS) or hantavirus cardiopulmonary syndrome (HCPS). In this Review, we discuss the basic molecular properties and cell biology of hantaviruses and offer an overview of virus-induced pathology, in particular vascular leakage and immunopathology.
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