Phenotypic characterization of lung macrophages in asthmatic patients: overexpression of CCL17
KJ Staples, TSC Hinks, JA Ward, V Gunn… - Journal of allergy and …, 2012 - Elsevier
BACKGROUND: Studies with monocyte-derived macrophages (MDMs) and animal models
have suggested a role for alternatively activated (M2) macrophages in asthmatic
inflammation, but in vivo evidence for this phenotype in human asthma is lacking.
OBJECTIVE: To characterize the phenotype of lung macrophages from asthmatic patients in
relation to disease severity and treatment. METHODS: M2 biomarkers were first identified by
using MDMs exposed to TH2 cytokines and then used to phenotype sputum and …
have suggested a role for alternatively activated (M2) macrophages in asthmatic
inflammation, but in vivo evidence for this phenotype in human asthma is lacking.
OBJECTIVE: To characterize the phenotype of lung macrophages from asthmatic patients in
relation to disease severity and treatment. METHODS: M2 biomarkers were first identified by
using MDMs exposed to TH2 cytokines and then used to phenotype sputum and …