Memory and effector CD8 T-cell responses after nanoparticle vaccination of melanoma patients
DE Speiser, K Schwarz, P Baumgaertner… - Journal of …, 2010 - journals.lww.com
Induction of cytotoxic CD8 T-cell responses is enhanced by the exclusive presentation of
antigen through dendritic cells, and by innate stimuli, such as toll-like receptor ligands. On
the basis of these 2 principles, we designed a vaccine against melanoma. Specifically, we
linked the melanoma-specific Melan-A/Mart-1 peptide to virus-like nanoparticles loaded with
A-type CpG, a ligand for toll-like receptor 9. Melan-A/Mart-1 peptide was cross-presented, as
shown in vitro with human dendritic cells and in HLA-A2 transgenic mice. A phase I/II study …
antigen through dendritic cells, and by innate stimuli, such as toll-like receptor ligands. On
the basis of these 2 principles, we designed a vaccine against melanoma. Specifically, we
linked the melanoma-specific Melan-A/Mart-1 peptide to virus-like nanoparticles loaded with
A-type CpG, a ligand for toll-like receptor 9. Melan-A/Mart-1 peptide was cross-presented, as
shown in vitro with human dendritic cells and in HLA-A2 transgenic mice. A phase I/II study …