[HTML][HTML] The REV7 subunit of DNA polymerase ζ is essential for primordial germ cell maintenance in the mouse
N Watanabe, S Mii, N Asai, M Asai, K Niimi… - Journal of Biological …, 2013 - ASBMB
REV7 (also known as MAD2L2 and MAD2B) is involved in DNA repair, cell cycle regulation,
gene expression, and carcinogenesis. In vitro studies show that REV7 interacts with several
proteins and regulates their function. It has been reported that human REV7 is highly
expressed in the adult testis by Northern blot analysis. However, the significance of REV7 in
mammalian development has not been elucidated. Here, we present analyses of REV7-
deficient (Rev7−/−) mice to clarify the significance of Rev7 in mouse development. In WT …
gene expression, and carcinogenesis. In vitro studies show that REV7 interacts with several
proteins and regulates their function. It has been reported that human REV7 is highly
expressed in the adult testis by Northern blot analysis. However, the significance of REV7 in
mammalian development has not been elucidated. Here, we present analyses of REV7-
deficient (Rev7−/−) mice to clarify the significance of Rev7 in mouse development. In WT …