Effects of ions and ionic channel activators or blockers on release of α-MSH from perifused rat hypothalamic slices
DT Bunel, C Delbende, C Blasquez, S Jégou… - Molecular Brain …, 1990 - Elsevier
The involvement of sodium and chloride ions in the process of α-melanocyte-stimulating
hormone (α-MSH) release from hypothalamic neurons was investigated using perifused rat
hypothalamic slices. Three different stimuli were found to increase α-MSH release from
hypothalamic slices: high K+ concentration (50 mM), veratridine (50 μM), and the Na+ K+-
ATPase inhibitor ouabain (1 mM). Spontaneous or K+-evoked α-MSH release was
insensitive to the specific Na+ channel blocker tetrodotoxin (TTX; 1.5 μM) and to the blocker …
hormone (α-MSH) release from hypothalamic neurons was investigated using perifused rat
hypothalamic slices. Three different stimuli were found to increase α-MSH release from
hypothalamic slices: high K+ concentration (50 mM), veratridine (50 μM), and the Na+ K+-
ATPase inhibitor ouabain (1 mM). Spontaneous or K+-evoked α-MSH release was
insensitive to the specific Na+ channel blocker tetrodotoxin (TTX; 1.5 μM) and to the blocker …