Calbindin and parvalbumin are early markers of non-mitotically regenerating hair cells in the bullfrog vestibular otolith organs
PS Steyger, M Burton, JR Hawkins, NR Schuff… - International Journal of …, 1997 - Elsevier
Earlier studies have demonstrated hair cell regeneration in the absence of cell proliferation,
and suggested that supporting cells could phenotypically convert into hair cells following
hair cell loss. Because calcium-binding proteins are involved in gene up-regulation, cell
growth, and cell differentiation, we wished to determine if these proteins were up-regulated
in scar formations and regenerating hair cells following gentamicin treatment. Calbindin and
parvalbumin immunolabeling was examined in control or gentamicin-treated (GT) bullfrog …
and suggested that supporting cells could phenotypically convert into hair cells following
hair cell loss. Because calcium-binding proteins are involved in gene up-regulation, cell
growth, and cell differentiation, we wished to determine if these proteins were up-regulated
in scar formations and regenerating hair cells following gentamicin treatment. Calbindin and
parvalbumin immunolabeling was examined in control or gentamicin-treated (GT) bullfrog …