[HTML][HTML] Evidence that antibiotics bind to human mitochondrial ribosomal RNA has implications for aminoglycoside toxicity
Aminoglycosides are a well known antibiotic family used to treat bacterial infections in
humans and animals, but which can be toxic. By binding to the decoding site of helix44 of
the small subunit RNA of the bacterial ribosome, the aminoglycoside antibiotics inhibit
protein synthesis, cause misreading, or obstruct peptidyl-tRNA translocation. Although
aminoglycosides bind helix69 of the bacterial large subunit RNA as well, little is known
about their interaction with the homologous human helix69. To probe the role this binding …
humans and animals, but which can be toxic. By binding to the decoding site of helix44 of
the small subunit RNA of the bacterial ribosome, the aminoglycoside antibiotics inhibit
protein synthesis, cause misreading, or obstruct peptidyl-tRNA translocation. Although
aminoglycosides bind helix69 of the bacterial large subunit RNA as well, little is known
about their interaction with the homologous human helix69. To probe the role this binding …