Reduced human herpesvirus-8 oropharyngeal shedding associated with protease inhibitor-based antiretroviral therapy
S Gantt, A Cattamanchi, E Krantz, A Magaret… - Journal of Clinical …, 2014 - Elsevier
Abstract Background Human herpesvirus 8 (HHV-8) replication increases the risk of Kaposi
sarcoma (KS). Highly-active antiretroviral therapy (HAART) reduces the incidence of KS, and
regimens that contain protease inhibitors (PIs) may be particularly effective. Objective To
determine whether PI-based HAART regimens may more effectively inhibit HHV-8 shedding
compared to regimens without PIs. Study design Prospective, observational study of 142 HIV-
1 and HHV-8 co-infected men conducted in Seattle, Washington. Quantitative HHV-8 PCR …
sarcoma (KS). Highly-active antiretroviral therapy (HAART) reduces the incidence of KS, and
regimens that contain protease inhibitors (PIs) may be particularly effective. Objective To
determine whether PI-based HAART regimens may more effectively inhibit HHV-8 shedding
compared to regimens without PIs. Study design Prospective, observational study of 142 HIV-
1 and HHV-8 co-infected men conducted in Seattle, Washington. Quantitative HHV-8 PCR …