[CITATION][C] The elastase-antielastase hypothesis of the pathogenesis of emphysema
PJ Stone - Clinics in chest medicine, 1983 - Elsevier
There have been significant advances during the last two decades in our understanding of
the biochemical processes that may underlie pulmonary emphysema. A landmark discovery
by Laurell and Eriksson" in 1963 linked a deficiency of alpha-l-protease inhibitor, a plasma
protein, to the frequent occurrence of emphysema. Known then as alpha-l-antitrypsin
because of its ability to irreversibly inhibit the proteolytic activity of trypsin, the protein
migrated in the alpha-I band of serum proteins during the electrophoresis of serum samples …
the biochemical processes that may underlie pulmonary emphysema. A landmark discovery
by Laurell and Eriksson" in 1963 linked a deficiency of alpha-l-protease inhibitor, a plasma
protein, to the frequent occurrence of emphysema. Known then as alpha-l-antitrypsin
because of its ability to irreversibly inhibit the proteolytic activity of trypsin, the protein
migrated in the alpha-I band of serum proteins during the electrophoresis of serum samples …