The induction of emphysema with elastase. I. The evolution of the lesion and the influence of serum
PD Kaplan, C Kuhn, JA Pierce - The Journal of laboratory and …, 1973 - translationalres.com
Proteolytic enzymes have been implicated in the pathogenesis of emphysema. Enzymes
previously used to induce emphysema in animals share the property of actively degrading
elastin, but also have other proteolytic activities. To investigate the capacity of elastase to
produce emphysema, Syrian hamsters were injected intratracheally with 25 units of porcine
pancreatic elastase and animals killed at intervals of up to 2 months. Elastase activity
measured in lung homogenates declined rapidly and was barely detectable in lungs 4 hours …
previously used to induce emphysema in animals share the property of actively degrading
elastin, but also have other proteolytic activities. To investigate the capacity of elastase to
produce emphysema, Syrian hamsters were injected intratracheally with 25 units of porcine
pancreatic elastase and animals killed at intervals of up to 2 months. Elastase activity
measured in lung homogenates declined rapidly and was barely detectable in lungs 4 hours …