[HTML][HTML] Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production
The HIV-1 Rev protein plays a key role in the late phase of virus replication. It binds to the
Rev Response Element found in underspliced HIV mRNAs, and drives their nuclear export
by the CRM1 receptor pathway. Moreover, mounting evidence suggests that Rev has
additional functions in viral replication. Here we employed proteomics and statistical
analysis to identify candidate host cell factors that interact with Rev. For this we studied Rev
complexes assembled in vitro with nuclear or cytosolic extracts under conditions emulating …
Rev Response Element found in underspliced HIV mRNAs, and drives their nuclear export
by the CRM1 receptor pathway. Moreover, mounting evidence suggests that Rev has
additional functions in viral replication. Here we employed proteomics and statistical
analysis to identify candidate host cell factors that interact with Rev. For this we studied Rev
complexes assembled in vitro with nuclear or cytosolic extracts under conditions emulating …