[HTML][HTML] Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation
B Maiti, J Li, A De Bruin, F Gordon, C Timmers… - Journal of Biological …, 2005 - ASBMB
The E2F transcription factor family plays a crucial and well established role in cell cycle
progression. Deregulation of E2F activities in vivo leads to developmental defects and
cancer. Based on current evidence in the field, mammalian E2Fs can be functionally
categorized into either transcriptional activators (E2F1, E2F2, and E2F3a) or repressors
(E2F3b, E2F4, E2F5, E2F6, and E2F7). We have identified a novel E2F family member,
E2F8, which is conserved in mice and humans and has its counterpart in Arabidopsis …
progression. Deregulation of E2F activities in vivo leads to developmental defects and
cancer. Based on current evidence in the field, mammalian E2Fs can be functionally
categorized into either transcriptional activators (E2F1, E2F2, and E2F3a) or repressors
(E2F3b, E2F4, E2F5, E2F6, and E2F7). We have identified a novel E2F family member,
E2F8, which is conserved in mice and humans and has its counterpart in Arabidopsis …