In Vivo Changes After Mechanical Injury.

CW Colwell Jr, DD D'Lima, HR Hoenecke… - … Research (1976-2007 …, 2001 - journals.lww.com
Chondrocytes undergo apoptosis in response to mechanical injury in vitro. The current
clinical study correlates arthroscopic and magnetic resonance imaging results with biopsy
specimens of cartilage from patients with knee injury. Twenty patients were evaluated at a
mean 2.7 months after acute knee injury. The mean age of the patients was 32 years and the
mean weight was 83 kg. Cartilage lesions were graded separately on magnetic resonance
images and arthroscopy in a blinded manner. During arthroscopy, a 1.8 mm diameter biopsy …