Targeted disruption of the apolipoprotein C-III gene in mice results in hypotriglyceridemia and protection from postprandial hypertriglyceridemia.
N Maeda, H Li, D Lee, P Oliver, SH Quarfordt… - Journal of Biological …, 1994 - ASBMB
Using gene targeting in embryonic stem cells, we have generated mice lacking
apolipoprotein C-III (ApoC-III). Homozygous mutant animals show absence of ApoC-III
protein and no expression of ApoC-III mRNA in the liver or in the intestine. Expression of the
neighboring genes, coding for apolipoprotein AI and apolipoprotein A-IV, are not altered in
the liver but are reduced in the intestine. This suggests that these three genes share a tissue-
specific element for intestinal expression and that insertion of an additional promoter for the …
apolipoprotein C-III (ApoC-III). Homozygous mutant animals show absence of ApoC-III
protein and no expression of ApoC-III mRNA in the liver or in the intestine. Expression of the
neighboring genes, coding for apolipoprotein AI and apolipoprotein A-IV, are not altered in
the liver but are reduced in the intestine. This suggests that these three genes share a tissue-
specific element for intestinal expression and that insertion of an additional promoter for the …