[HTML][HTML] Adenovirus-mediated rescue of lipoprotein lipase-deficient mice: lipolysis of triglyceride-rich lipoproteins is essential for high density lipoprotein maturation in …
JG Strauss, S Frank, D Kratky, G Hämmerle… - Journal of Biological …, 2001 - ASBMB
Lipoprotein lipase (LPL) is the rate-limiting enzyme for the hydrolysis of triglycerides and the
subsequent uptake of free fatty acids in extrahepatic tissues. Deficiency of LPL in humans
(Type I hyperlipoproteinemia) is associated with massive chylomicronemia, low high density
lipoprotein (HDL) cholesterol levels, and recurrent attacks of pancreatitis when not
controlled by a strict diet. In contrast to humans, homozygous LPL knock-out mice (L0) do
not survive suckling and die between 18 and 24 h after birth. In this study, an adenovirus …
subsequent uptake of free fatty acids in extrahepatic tissues. Deficiency of LPL in humans
(Type I hyperlipoproteinemia) is associated with massive chylomicronemia, low high density
lipoprotein (HDL) cholesterol levels, and recurrent attacks of pancreatitis when not
controlled by a strict diet. In contrast to humans, homozygous LPL knock-out mice (L0) do
not survive suckling and die between 18 and 24 h after birth. In this study, an adenovirus …