[HTML][HTML] Chylomicron-and VLDL-derived lipids enter the heart through different pathways: in vivo evidence for receptor-and non-receptor-mediated fatty acid uptake
KG Bharadwaj, Y Hiyama, Y Hu, LA Huggins… - Journal of biological …, 2010 - ASBMB
Lipids circulate in the blood in association with plasma lipoproteins and enter the tissues
either after hydrolysis or as non-hydrolyzable lipid esters. We studied cardiac lipids,
lipoprotein lipid uptake, and gene expression in heart-specific lipoprotein lipase (LpL) knock-
out (hLpL0), CD36 knock-out (Cd36−/−), and double knock-out (hLpL0/Cd36−/−-DKO) mice.
Loss of either LpL or CD36 led to a significant reduction in heart total fatty acyl-CoA (control,
99.5±3.8; hLpL0, 36.2±3.5; Cd36−/−, 57.7±5.5 nmol/g, p< 0.05) and an additive effect was …
either after hydrolysis or as non-hydrolyzable lipid esters. We studied cardiac lipids,
lipoprotein lipid uptake, and gene expression in heart-specific lipoprotein lipase (LpL) knock-
out (hLpL0), CD36 knock-out (Cd36−/−), and double knock-out (hLpL0/Cd36−/−-DKO) mice.
Loss of either LpL or CD36 led to a significant reduction in heart total fatty acyl-CoA (control,
99.5±3.8; hLpL0, 36.2±3.5; Cd36−/−, 57.7±5.5 nmol/g, p< 0.05) and an additive effect was …