[HTML][HTML] Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice
MM Weinstein, L Yin, AP Beigneux, BSJ Davies… - Journal of biological …, 2008 - ASBMB
GPIHBP1-deficient mice (Gpihbp1–/–) exhibit severe chylomicronemia. GPIHBP1 is located
within capillaries of muscle and adipose tissue, and expression of GPIHBP1 in Chinese
hamster ovary cells confers upon those cells the ability to bind lipoprotein lipase (LPL).
However, there has been absolutely no evidence that GPIHBP1 actually interacts with LPL
in vivo. Heparin is known to release LPL from its in vivo binding sites, allowing it to enter the
plasma. After an injection of heparin, we reasoned that LPL bound to GPIHBP1 in capillaries …
within capillaries of muscle and adipose tissue, and expression of GPIHBP1 in Chinese
hamster ovary cells confers upon those cells the ability to bind lipoprotein lipase (LPL).
However, there has been absolutely no evidence that GPIHBP1 actually interacts with LPL
in vivo. Heparin is known to release LPL from its in vivo binding sites, allowing it to enter the
plasma. After an injection of heparin, we reasoned that LPL bound to GPIHBP1 in capillaries …