[HTML][HTML] Apolipoprotein C-III deficiency accelerates triglyceride hydrolysis by lipoprotein lipase in wild-type and apoE knockout mice
MC Jong, PCN Rensen, VEH Dahlmans… - Journal of lipid …, 2001 - ASBMB
Previous studies with hypertriglyceridemic APOC3 transgenic mice have suggested that
apolipoprotein C-III (apoC-III) may inhibit either the apoE-mediated hepatic uptake of TG-rich
lipoproteins and/or the lipoprotein lipase (LPL)-mediated hydrolysis of TG. Accordingly,
apoC3 knockout (apoC3−/−) mice are hypotriglyceridemic. In the present study, we
attempted to elucidate the mechanism (s) underlying these phenomena by intercrossing
apoC3−/− mice with apoE−/− mice to study the effects of apoC-III deficiency against a …
apolipoprotein C-III (apoC-III) may inhibit either the apoE-mediated hepatic uptake of TG-rich
lipoproteins and/or the lipoprotein lipase (LPL)-mediated hydrolysis of TG. Accordingly,
apoC3 knockout (apoC3−/−) mice are hypotriglyceridemic. In the present study, we
attempted to elucidate the mechanism (s) underlying these phenomena by intercrossing
apoC3−/− mice with apoE−/− mice to study the effects of apoC-III deficiency against a …